September 2025

IGNOU BBCET-145 Assignment 2025 – All Answers Master Page

IGNOU Assignment 2025 Course Title: Molecular Basis of Non-infectious Human Diseases Course Code: BBCET-145 Assignment Code: BBCET-145/TMA/2025 Maximum Marks: 100 Note: Attempt all questions. The marks for each question are indicated against it. Write the answers in your own words; do not copy from the course material. PART A a) Define the balance diet. Explain

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What is familial hypercholesterolemia? Discuss its molecular basis, symptoms and treatments.

Introduction Familial Hypercholesterolemia (FH) is an inherited disorder characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C), commonly known as “bad cholesterol,” in the blood. It significantly increases the risk of early-onset cardiovascular diseases such as heart attack and stroke. FH is one of the most common genetic lipid disorders and can be passed

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Write the causes and symptoms of the following inherited disorders: a) Alkaptonuria b) Phenylketonuria

Introduction Inherited metabolic disorders are genetic conditions that result from defects in specific enzymes involved in metabolism. Two classic examples are Alkaptonuria and Phenylketonuria (PKU). These disorders are autosomal recessive, meaning a child must inherit defective genes from both parents to be affected. Early diagnosis and management are critical to prevent complications. a) Alkaptonuria Cause:

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Describe the pathophysiology of Alzheimer’s disease. What is the role of amyloid beta plaque and tau protein?

Introduction Alzheimer’s disease is a progressive neurodegenerative disorder that primarily affects the elderly. It leads to memory loss, cognitive decline, and behavioral changes. It is the most common cause of dementia. The exact cause is not fully understood, but it involves complex interactions of genetic, environmental, and lifestyle factors. Two hallmark features of Alzheimer’s disease

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Define anxiety. Write symptoms, category and causes of anxiety.

Introduction Anxiety is a normal emotional response to stress or danger. It is characterized by feelings of tension, worry, and physical changes like increased heart rate and sweating. While occasional anxiety is a normal part of life, chronic or intense anxiety that interferes with daily functioning may indicate an anxiety disorder. Definition of Anxiety Anxiety

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Discuss the role of proto-oncogenes and tumor suppressor genes in the development of cancer. Give example of each.

Introduction Cancer is a genetic disease caused by mutations that alter the regulation of cell growth and division. Two major types of genes involved in the development of cancer are proto-oncogenes and tumor suppressor genes. When these genes are altered, they disrupt the normal control of cell cycle, leading to uncontrolled cell growth — the

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