2025

Enlist any two inhibitors of nucleotide synthesis with their mechanism of action, enzyme inhibited and their use in medicine

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Enlist Any Two Inhibitors of Nucleotide Synthesis With Their Mechanism of Action, Enzyme Inhibited, and Their Use in Medicine Nucleotide synthesis inhibitors are crucial in medicine, particularly in cancer therapy, autoimmune diseases, and transplant medicine. Here are two well-known inhibitors: 1. Methotrexate Mechanism of Action: Methotrexate is a folate analog that inhibits dihydrofolate reductase (DHFR), […]

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Explain the structure of type I RNR

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Explain the Structure of Type I RNR Ribonucleotide reductase (RNR) is an essential enzyme responsible for reducing ribonucleotides into deoxyribonucleotides, which are the building blocks of DNA. Type I RNR is the most studied form and is found in many organisms, including bacteria and eukaryotes. Subunit Composition Large Subunit (R1 or α-subunit): Contains the catalytic

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How purine synthesis is regulated?

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How Purine Synthesis is Regulated? Purine nucleotide synthesis is tightly regulated to ensure a balanced supply of purines for DNA, RNA, and energy metabolism. The regulatory mechanisms maintain the correct levels of adenine (AMP) and guanine (GMP) nucleotides while avoiding excess buildup that could be wasteful or toxic. Key Regulatory Points in Purine Synthesis 1.

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Explain de novo synthesis of UMP. Describe the steps

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Explain De Novo Synthesis of UMP. Describe the Steps Uridine monophosphate (UMP) is a pyrimidine nucleotide that plays a fundamental role in RNA synthesis. In cells, UMP can be synthesized by the de novo pathway from basic precursor molecules including glutamine, aspartate, and bicarbonate. This pathway does not require preformed bases but builds the pyrimidine

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What are catecholamines?

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What Are Catecholamines? Catecholamines are a group of chemically related neurotransmitters and hormones that are derived from the amino acid tyrosine. The primary catecholamines are dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). Biosynthesis The synthesis of catecholamines occurs mainly in the adrenal medulla and the central nervous system. The pathway involves the following steps: Tyrosine →

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Describe biosynthesis of non essential amino acids of aromatic amino acid family

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Describe Biosynthesis of Non-Essential Amino Acids of Aromatic Amino Acid Family The aromatic amino acid family primarily includes phenylalanine, tyrosine, and tryptophan. Among them, tyrosine is considered non-essential because it can be synthesized from phenylalanine in humans. Tryptophan and phenylalanine are essential and must be obtained from the diet. 1. Tyrosine Biosynthesis Tyrosine is synthesized

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Explain the following disorders of amino acid metabolism: Homocystinuria and Hartnup disease

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Explain the Following Disorders of Amino Acid Metabolism: Homocystinuria and Hartnup Disease a) Homocystinuria Homocystinuria is an inherited disorder caused by a deficiency in the enzyme cystathionine beta-synthase (CBS), which leads to the accumulation of homocysteine and methionine in the blood and urine. This disorder is typically inherited in an autosomal recessive pattern. Causes and

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Explain the catabolism of amino acids that are converted to pyruvate

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Explain the Catabolism of Amino Acids That Are Converted to Pyruvate Amino acids can be classified as glucogenic, ketogenic, or both based on the end products of their catabolism. Glucogenic amino acids are converted into intermediates that enter the gluconeogenesis pathway, such as pyruvate. Several amino acids—specifically alanine, serine, cysteine, glycine, threonine, and tryptophan—can be

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Write short note on Marasmus

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Write Short Note on Marasmus Marasmus is a severe form of protein-energy malnutrition that typically affects children under the age of five, especially in developing countries. It results from a prolonged deficiency in calorie intake, including proteins, carbohydrates, and fats. Causes Chronic undernutrition due to poverty or food scarcity Repeated infections that increase nutrient requirements

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