Lipid Metabolism

What is ceramide? How is sphingomyelin synthesized from ceramide?

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Ceramide and Sphingomyelin Synthesis What is Ceramide? Ceramide is a central molecule in the metabolism of sphingolipids. It consists of a sphingosine backbone (an 18-carbon amino alcohol with an unsaturated hydrocarbon chain) linked to a fatty acid via an amide bond. Ceramide acts as both a structural lipid component of membranes and a signaling molecule […]

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Describe the CPD-base pathway for phosphatidyl choline synthesis

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CPD-Base Pathway for Phosphatidylcholine Synthesis Introduction Phosphatidylcholine (PC) is one of the most abundant phospholipids in eukaryotic membranes. It plays crucial roles in membrane structure, lipid metabolism, and signaling. The CDP-choline pathway (also known as the Kennedy pathway) is the major route for PC biosynthesis in mammalian cells. Steps of the CDP-Choline (Kennedy) Pathway The

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Explain DAG transacylase pathway for triglyceride synthesis

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DAG Transacylase Pathway for Triglyceride Synthesis Introduction Triglyceride (triacylglycerol) synthesis is a crucial biochemical process that stores energy in adipose tissues. The diacylglycerol acyltransferase (DGAT) enzyme plays a central role in the final step of triglyceride synthesis through the DAG transacylase pathway. Overview of Triglyceride Synthesis Triglycerides are composed of one glycerol molecule and three

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What is the role of fatty acid synthase complex in fatty acid metabolism?

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Role of Fatty Acid Synthase Complex in Fatty Acid Metabolism Introduction The fatty acid synthase (FAS) complex is a multi-enzyme protein responsible for catalyzing the synthesis of long-chain saturated fatty acids from acetyl-CoA and malonyl-CoA precursors. It plays a vital role in lipid metabolism and energy storage, particularly in the liver, adipose tissue, and mammary

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